{"id":18046,"date":"2022-12-22T12:13:21","date_gmt":"2022-12-22T12:13:21","guid":{"rendered":"https:\/\/iiser.ntc-us.com\/iisernew\/?p=18046"},"modified":"2023-02-03T07:29:44","modified_gmt":"2023-02-03T07:29:44","slug":"rna-based-genome-surveillance-mechanisms","status":"publish","type":"post","link":"https:\/\/iiser.ntc-us.com\/iisernew\/rna-based-genome-surveillance-mechanisms\/","title":{"rendered":"RNA-based Genome Surveillance Mechanisms"},"content":{"rendered":"<p><strong>Title<\/strong> : RNA-based Genome Surveillance Mechanisms.<br \/>\n<strong>Speaker<\/strong> : Dr. Sree Rama Chaitanya Sridhara, Research Associate, CDFD, Hyderabad<br \/>\n<strong>Date<\/strong> : 11\/10\/2022, 05:30 PM , Ramanujan Hall, IISER Tirupati Transit Campus.<\/p>\n<p><strong>Abstract:\u00a0 <\/strong>Co-transcriptional R-loops (or RNA-DNA hybrids) came far from being simple by-products of transcription to crucial players in genome structure and function. But it was not known how cells sense and signal aberrant R-loops, which if left unresolved could damage DNA. In this regard, we reported that aberrant pausing of RNA polymerase II (RNA Pol II) initiates a signalling cascade whereby the serine\/arginine protein kinase 2 (SRPK2) phosphorylates the DEAD-box helicase 23 (DDX23), culminating in the suppression of R-loops. We were the first to describe the role of SRPK2 and DDX23 in R-loop biology and propose that RNA Pol II transcription dynamics could signal aberrant R-loops.<\/p>\n<p>(<a href=\"https:\/\/doi.org\/10.1101\/2022.06.20.496844\">https:\/\/doi.org\/10.1101\/2022.06.20.496844<\/a>\u00a0@CDFD, India).<\/p>\n<p><strong><u>Bio sketch:<\/u><\/strong><\/p>\n<p>I did my Master&#8217;s in Advanced Biochemistry (2009) from the University of Chennai and later worked as a junior researcher at the AU-KBC research center (Chennai, 2011) on the cell biology of nitric oxide signaling in endothelial cell function and angiogenesis. Then I went to the Institute of Molecular Medicine in Lisbon, Portugal with a Boehringer Ingelheim Fonds and Marie Sklodowska-Curie fellowship to pursue my Ph.D. (2017) in RNA splicing\u00a0mechanisms\u00a0and DNA damage response. I then continued as a postdoc in the same institute until I returned to India (just before the pandemic). Later I joined CDFD as a research associate and now looking for exciting positions to do research in understanding how\u00a0RNA-based\u00a0mechanisms\u00a0support\u00a0genome\u00a0maintenance\u00a0(a short video, if necessary,\u00a0<a href=\"https:\/\/drive.google.com\/file\/d\/11Rjeo1Z_XMofQCTaK9cX-JckVPrJ6ANl\/view\">here<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p><strong>Date<\/strong> : 11\/10\/2022, 05:30 PM<\/p>\n","protected":false},"author":8,"featured_media":21956,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_expiration-date-status":"","_expiration-date":0,"_expiration-date-type":"","_expiration-date-categories":[],"_expiration-date-options":[]},"categories":[109],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/18046"}],"collection":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/comments?post=18046"}],"version-history":[{"count":6,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/18046\/revisions"}],"predecessor-version":[{"id":23246,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/18046\/revisions\/23246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/media\/21956"}],"wp:attachment":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/media?parent=18046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/categories?post=18046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/tags?post=18046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}