{"id":17916,"date":"2022-12-21T15:43:59","date_gmt":"2022-12-21T15:43:59","guid":{"rendered":"https:\/\/iiser.ntc-us.com\/iisernew\/?p=17916"},"modified":"2023-02-03T07:28:41","modified_gmt":"2023-02-03T07:28:41","slug":"demystifying-the-early-events-of-protein-aggregation-in-neurodegenerative-diseases","status":"publish","type":"post","link":"https:\/\/iiser.ntc-us.com\/iisernew\/demystifying-the-early-events-of-protein-aggregation-in-neurodegenerative-diseases\/","title":{"rendered":"Demystifying the Early Events of Protein Aggregation in Neurodegenerative Diseases"},"content":{"rendered":"<p><strong>Title<\/strong> : Demystifying the Early Events of Protein Aggregation in Neurodegenerative Diseases.<br \/>\n<strong>Speaker<\/strong> : Dr Krishnananda Chattopadhyay, Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, Kolkata<br \/>\n<strong>Date<\/strong> : 02\/11\/2022, 05:30 PM , Online.<\/p>\n<p><strong>Abstract :<\/strong><\/p>\n<p>Protein\u00a0aggregation\u00a0and deposition has been found to be a common phenotype\u00a0in\u00a0multiple\u00a0neurodegenerative\u00a0diseases.\u00a0The\u00a0heterogeneity\u00a0of\u00a0aggregation\u00a0process and\u00a0the\u00a0presence\u00a0of\u00a0large number\u00a0of\u00a0triggering mechanisms results\u00a0in\u00a0the\u00a0difficulty to devise therapeutic strategies against these toxic inclusions formation. Our laboratory has been investigating these triggers, which contribute to\u00a0the\u00a0alteration\u00a0of\u00a0folding pathways leading to\u00a0the\u00a0early\u00a0and unexplored stages\u00a0of\u00a0aggregation.\u00a0The\u00a0conformational heterogeneity\u00a0of\u00a0the\u00a0early\u00a0intermediates and their transient nature are some\u00a0of\u00a0the\u00a0reasons why traditional techniques do not typically work for\u00a0the\u00a0early\u00a0stage detection. We have been using sensitive biophysical methods to directly detect and characterize\u00a0the\u00a0early\u00a0intermediates and oligomers\u00a0<em>in\u00a0vitro<\/em>\u00a0and inside live cells using Parkinson\u2019s\u00a0diseases\u00a0(PD) and ALS as our models. We are also using cryo-EM to investigate\u00a0the\u00a0structural insights into\u00a0the\u00a0early\u00a0intermediates, which are believed to\u00a0the\u00a0primary inducer\u00a0of\u00a0cellular toxicity. Using a combination\u00a0of\u00a0biophysics, biochemistry and microscopy, we are developing\u00a0protein\u00a0early\u00a0intermediates vs toxicity maps to determine\u00a0the\u00a0structural insights responsible for\u00a0the\u00a0neuronal toxicity.<\/p>\n<p><strong>About\u00a0the\u00a0speaker:<\/strong><\/p>\n<p>Krishnananda Chattopadhyay is currently a Chief Scientist and\u00a0the\u00a0Head\u00a0of\u00a0the\u00a0Structural Biology and Bioinformatics Division at CSIR-Indian Institute\u00a0of\u00a0Chemical Biology. His research group applies novel biochemical and biophysical tools at ensemble and single molecule resolution to study human\u00a0diseases\u00a0with particular emphasis to neurodegeneration and infections. He obtained his PhD degree from Tata Institute\u00a0of\u00a0Fundamental Research, Mumbai. He then moved to Washington University School\u00a0of\u00a0Medicine, Saint Louis, USA for his postdoctoral research. Before joining CSIR-Indian Institute\u00a0of\u00a0Chemical Biology\u00a0in\u00a02006, he worked at Pfizer, USA as a Senior Scientist.\u00a0 He is a fellow\u00a0of\u00a0Royal Society\u00a0of\u00a0Chemistry and West Bengal Academy\u00a0of\u00a0Science and Technology. He is also a fellow\u00a0of\u00a0Indo-US Science and Technology Forum and a recipient\u00a0of\u00a0American Chemical Society Membership Award. He is current\u00a0the\u00a0Lead\u00a0of\u00a0the\u00a0Biophysics and Structural Biology Section\u00a0of\u00a0the\u00a0Editorial Board\u00a0of\u00a0Communications Biology, a Nature Research Journal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><strong>Date<\/strong> : 02\/11\/2022, 05:30 PM<\/p>\n","protected":false},"author":8,"featured_media":21956,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_expiration-date-status":"","_expiration-date":0,"_expiration-date-type":"","_expiration-date-categories":[],"_expiration-date-options":[]},"categories":[109],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/17916"}],"collection":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/comments?post=17916"}],"version-history":[{"count":7,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/17916\/revisions"}],"predecessor-version":[{"id":23253,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/17916\/revisions\/23253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/media\/21956"}],"wp:attachment":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/media?parent=17916"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/categories?post=17916"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/tags?post=17916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}