{"id":17881,"date":"2022-12-21T14:30:43","date_gmt":"2022-12-21T14:30:43","guid":{"rendered":"https:\/\/iiser.ntc-us.com\/iisernew\/?p=17881"},"modified":"2023-02-03T07:28:16","modified_gmt":"2023-02-03T07:28:16","slug":"structure-aggregation-and-seeding-properties-of-amyloid-proteins-associated-with-neurodegenerative-diseases","status":"publish","type":"post","link":"https:\/\/iiser.ntc-us.com\/iisernew\/structure-aggregation-and-seeding-properties-of-amyloid-proteins-associated-with-neurodegenerative-diseases\/","title":{"rendered":"Structure, Aggregation and Seeding Properties of Amyloid Proteins Associated with Neurodegenerative Diseases"},"content":{"rendered":"

Title<\/strong> : Structure, Aggregation and Seeding Properties of Amyloid Proteins Associated with Neurodegenerative Diseases.
\nSpeaker<\/strong> : Dr. Senthil Kumar Thangaraj, EPFL, Lausanne, Switzerland
\nDate<\/strong> : 11\/11\/2022, 05:30 PM , Classroom 1.<\/p>\n

Abstract:<\/strong><\/p>\n

Neurodegenerative diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) are fatal but clinically distinctive disorders. These diseases, in common, are pathologically characterized by the presence\u00a0of\u00a0abnormal\u00a0aggregation\u00a0of\u00a0one or many cellular\u00a0proteins\u00a0in different cell types, thus exhibiting different distributions\u00a0of\u00a0neurodegeneration. For example, TDP-43 in ALS\/FTLD and a-synuclein in PD are the\u00a0proteins\u00a0that undergo aberrant\u00a0aggregation. Enormous efforts have been underway to investigate the\u00a0structure\u00a0and formation\u00a0of\u00a0these pathological aggregates in vitro and in pre-clinical cellular models to understand the associated disease mechanisms and ultimately to develop novel strategies for diagnostic and therapeutic purposes. To gain insight into these, in my post-doctoral work, we worked on aims that employed multi-disciplinary approaches from structural biology to cell biology. In this presentation, I will talk about: 1) the knowledge that we gained on the sequence and structural determinants\u00a0of\u00a0TDP-43\u00a0aggregation\u00a0and its proteolytic events that might lead to its neurotoxicity in ALS\/FTLD1 ; 2) the efforts that we made for the development\u00a0of\u00a0the methods and tools for advancing research and drug discovery efforts in PD and other synucleinopathies2- 4 . Finally, I will also discuss how our current findings raise important questions that set the basis for my future research objectives.<\/p>\n

 <\/p>\n

Reference:<\/strong><\/p>\n

1) Kumar ST, Nazarov S, Porta S, Maharjan N, Cendrowska U, Kabani M, Finamore F, Xu Y, Lee VMY, Lashuel HA. Unmasking the\u00a0amyloid\u00a0core\u00a0of\u00a0full-length TDP-43 filaments is a key determinant\u00a0of\u00a0their\u00a0seeding\u00a0activity (Revision in Nature Neuroscience).<\/p>\n

2) Kumar ST, Mahul-Mellier AL, Hegde RN, Rivi\u00e8re G, Moons R, Ib\u00e1\u00f1ez de Opakua A, Magalh\u00e3es P, Rostami I, Donzelli S, Sobott F, Zweckstetter M, Lashuel HA. A NAC domain mutation (E83Q) unlocks the pathogenicity\u00a0of\u00a0human alpha-synuclein and recapitulates its pathological diversity. Sci Adv. 2022\u00a0Apr 29;8(17):eabn0044.<\/p>\n

3) Kumar ST, Jagannath S, Francois C, Vanderstichele H, Stoops E and Lashuel HA. How specific are the conformation-specific \u03b1-synuclein antibodies? Neurobiol Dis. 2020 Dec; 146:105086<\/p>\n

4) Kumar ST, Donzelli S, Chiki A, Syed MMK and Lashuel HA. Towards improving experimental reproducibility in \u03b1-synuclein research. J Neurochem. 2020 Apr;153(1):103-119.<\/p>\n","protected":false},"excerpt":{"rendered":"

Date<\/strong> : 11\/11\/2022, 05:30 PM<\/p>\n","protected":false},"author":8,"featured_media":21956,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_expiration-date-status":"","_expiration-date":0,"_expiration-date-type":"","_expiration-date-categories":[],"_expiration-date-options":[]},"categories":[109],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/17881"}],"collection":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/comments?post=17881"}],"version-history":[{"count":6,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/17881\/revisions"}],"predecessor-version":[{"id":23255,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/posts\/17881\/revisions\/23255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/media\/21956"}],"wp:attachment":[{"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/media?parent=17881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/categories?post=17881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iiser.ntc-us.com\/iisernew\/wp-json\/wp\/v2\/tags?post=17881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}