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Home  »  Pooja Yadav
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Pooja Yadav

Academic Background:

        I completed my Bachelors in chemistry from Daulat Ram College, University of Delhi. During my bachelors I become more interested in organic chemistry, which lead me to pursue my masters in organic specialization from kirorimal college, University of Delhi. Currently I am Pursuing PhD from IISER Tirupati. My research work mainly focuses on developing sustainable methodologies for the construction of interesting molecular scaffolds.
Pooja's Résumé

Research Interest

My current work is focused on developing a sustainable and robust methodology for C-H functionalization reactions. Sunlight is a renewable source of energy that provides us heat and light. Given the current scenario where non-renewable resources are at the verge of extinction, researchers have started looking for a renewable source of energy like solar energy, wind energy, etc. Inspired by this organic chemist also started looking for more greener and sustainable approaches for performing reactions. Photoredox catalysis has achieved this by using visible light as the energy source. C-H functionalization on the other hand plays a very important role in organic synthesis. Some of the key challenges in this arena is the lack of selectivity and reactivity of the C-H bond due to its lower acidity. This can be overcome by using transition metal catalysts, which facilitates the activation of unreactive C-H bonds.

We are also interested in exploring electro-organic synthesis for the construction of interesting molecular skeletons. Electro-organic synthesis generally replaces the use of oxidants and reductants with electricity, which make this method more sustainable and the conversions much milder.

Advisor Information

Dr. Gopinath is an Assistant Professor in the Chemistry department at IISER Tirupati. He completed his Ph.D. from the Dept. Of Organic Chemistry, Indian Institute of Science, Bangalore in 2011. He then moved to Tokyo, Japan, to work as a JSPS Postdoctoral Fellow at the Institute of Microbial Chemistry to work on asymmetric catalysis and synthesis. Subsequently, he worked as a postdoctoral research scientist in the Chemistry Department at Columbia University, New York, the U.S.A, on prebiotic chemistry.

His primary research focus is to develop new synthetic methods using catalysis as the main tool with a special focus on visible light photoredox catalysis, transition metal catalysis & dual catalysis. These synthetic methods will later be used for applications in the total synthesis of natural products, drugs & other bioactive compounds. He is a recipient of JSPS postdoctoral Fellowship, Ramanujan Fellowship, Early career research fellowship etc. He is a member of the American chemical society (2020-2021), Chemical research society of India (CRSI), & JSPS alumni association.

WRITE-UP FOR PMR FELLOWSHIP JUN 2021 - DEC 2021

Academic Progress

    1. Courses Done during PhD
      • Physical Organic Chemistry
      • Transition metal Chemistry
      • Organic Synthesis I
      • Organic Synthesis I
    2. Teaching Assistantships

             CHM 221- Organic chemistry in Second and Fourth semester

    3. Open Seminar
      • Title: Continuous Flow Chemistry in Organic Synthesis- Recent Trends
      • Date: 18/02/21
    4. Comprehensive Examination 
      • Date: 7/04/21
    5. RAC-1
      • Date: 30/08/2021
      • First RAC presentation involved 2 Chapters

 

Chapter 1

ortho- C-H functionalization of Aniline derivatives via Dual Electro-Organic Synthesis

Chapter 2

Multicomponent Reaction via Dual Photoredox catalysis

Thesis Objective

Aniline and its derivatives play a major role in pharmaceutical industries due to the presence of this core in various drugs like sulfanilamide, dapsone, procainamide etc. Hence functionalization of aniline and its derivatives could give access to several new structures with potential biological applications.

  • Simple C-H Functionalization of aniline and its derivatives via Electro-Organic Synthesis

Simple ortho C-H functionalization of aniline derivatives using a transition metal catalyst via electro-organic synthesis is currently            attempted with various functional groups such as aryl, trifluromethyl, acyl etc.  

Scheme 1: Functionalization of aniline and its derivatives

  • Functionalization of aniline and its derivatives via sequential addition coupling reactions using dual metallaphotoredox catalysis – Accessing highly functionalized aniline derivatives.

Different transition metal catalysts and photocatalysts such as Ru(bpy)3Cl2, Eosin Y etc. will be screened together with the additives and solvents to find the optimized reaction conditions using aniline or other aryl substrates as standard for the construction of a highly functionalized aniline derivative including heterocycles. If successful the methodology will be extended to different aniline derivatives and with different olefin partners and functional groups to demonstrate the versatility of the methodology.

  • Scheme 2: Reaction of anilines with olefins and other functional derivatives.

Publication

1. Aryl Diazonium Salts in Photoredox Catalysis – Recent Trends.

Sakamuri Sarath Babu, P. Muthuraja, Pooja Yadav and Purushothaman Gopinath.* Adv. Synth. Catal. 2021, 363, 1782-1809.