Author: Sai Kumar GA

Our group is focused on the following areas of research: Cell adhesion molecules (CAMs) in regulating neurogenesis, neurite outgrowth and degeneration; specific interactions among CAMs and their downstream signalling mechanisms. Molecular mechanisms of neuronal dysfunction in diabetic retinopathy. G-protein signalling in platelets and neutrophils.

Our research focuses on pathogenesis of severe malaria parasite where adhesion of parasites in the microvasculature leads to activation of stress signalling pathways in human host.

Our group works on understanding the molecular mechanisms of coregulators in signal transduction, Gene regulation, inflammation, Cancer progression and Cancer metastasis. Our research interests also include developing transgenic and knock out mouse models for studying the role of coregulator signalling in cancer and inflammatory disorders.

Our group focuses on deciphering the molecular mechanisms and the regulatory systems that enable plants to orchestrate complex root system architecture. Further, improvement of tolerance in crop plants to abiotic stresses (drought, salt and heavy metal) by improving root traits.

We work in the areas of Cancer Biology and Immunology. The focus is on how different signaling pathways regulate specific gene expression signatures in different cancer cell types and in the immune cells. While our major focus is on NF-kB signaling, which is abnormally activated in many cancer types and is the Central Pillar of… Continue reading Sivakumar Vallabhapurapu Research Area:

The focus of our research is circumscribed around understanding the biology of Mycobacterium species with an ultimate objective of developing strategies for successful interventions to stop the diseases (e.g. Tuberculosis) caused by these microorganism.

My programme relocated to IISER-Tirupati from TIFR-Mumbai very recently. I continue my research efforts at IISER-Tirupati that are mechanism-centric and are mainly directed towards two questions of cellular-molecular biology. How do chromosomes maintain quasi-stability against a variety of cellular stresses? We probe signaling mechanisms that lead to such genome-homeostasis in mammalian cells. Chlamydomonas reinhardtii, single… Continue reading B J Rao