Prolyl Polypeptides and Peptide Nucleic Acids (Prof K N Ganesh)

Our group is interested in the studying correlation of structure with self-assembling properties of 4(R/S)-(OH/NH2)-substituted prolyl polypeptides and collagen mimetics. Another area of interest is to enhance cell permeability Peptide Nucleic Acid (PNA) through cationic and fluorinated analogues towards potential application as antisense therapeutic agents and modulate their molecular recognition features through novel Janus PNA constructs. The objective is to fundamental understanding of the connections between molecular structures, conformation and self-assembly that dictate their biological activity and morphological features important for developing materials with new properties.